

While they attempt to convert Carlisle to his natural food source, their attempts were unsuccessful. Carlisle then moved on to the New World, there, he ended up working night shifts in a Chicago Hospital during Spanish Influenza Epidemic. During the epidemic, Carlisle encountered a dying woman named Elizabeth Masen. Her son, Edward, was dying of influenza as well. Elizabeth begged Carlisle to do anything within his power to save her son as she lay dying. Out of loneliness, and armed with the knowledge that Edward was alone in the world. he changed him, making him his companion.
Not long after, in 1921, Carlisle and Edward moved to Wisconsin, where Carlisle treated Esme after a failed suicide attempt spurred by the loss of her child. Carlisle felt compelled to save her life, having already treated her for a broken leg in her adolescence, and changed her as well. They soon fell in love and married.
Carlisle then turned Rosalie Hale, a young woman who was raped and almost killed by her drunken fiancé and his friends, who then left her in the street to die. Later, while hunting, Rosalie found a young man named Emmett who had been mauled by a bear. She carried him over 100 miles to Carlisle to be changed. Around 1950, Mary Alice Brandon and Jasper Whitlock joined his coven. Alice and Jasper met in Philadelphia, Pennsylvania in 1948, and sought out the Cullen's based on one of Alice's visions. Rosalie and Jasper pose as twins, taking the surname "Hale", while Alice changed her name to Cullen. (The whole of the Coven is referred to as "The Cullen's"), despite Rosalie and Jasper using the name "Hale".
Much later, Carlisle and his Family moved to Forks, Washington where they had lived previously (before Alice and Jasper joined them) and had made a treaty with th Quileute Tribe, led by a shape-shifter named Ephraim Black. The Treaty stated that the Quileute's would leave the Cullen's alone and not reveal them to the Humans if the Cullen's would Refrain from biting Humans - whether to kill or change them - or trespassing on Quileute Land. Because of the treaty, the Cullen's were able to live in relative peace.

Carlisle came up with his own theory as to why certain vampires have enhanced vampire existence. Carlisle is also immortal. and has had centuries to perfect his medical talents, becoming an excellent doctor. Unlike most vampires, after 300 years of practice he is no longer tempted by scent of human blood, and is able to use it to help him in the workplace, therefore turning his "curse" to his advantage. He also believes that every vampire's strongest ability is enhanced during their transformation. What he brought into his next life was his compassion.
Carlisle is a Celtic name meaning "Strong". This could refer to Carlisle's strong resistance from Human Blood. The Old English origin of the name is "Castle Tower", a clear indication of Carlisle's fortitude and the source of his family's own strength. A surname which was derived from an Old French form of Cologne, the name of a City in Germany.
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